अमूर्त

Diastereoselective Desymmetrization Of Meso Bis(Phenylsulfonyl) Polycyclic Alkenes Promoted By C2 Symmetric Chiral Diolates: Direct Access To Optically Pure Ketals And Ketones

Sergio Cossu, Paola Peluso


The desymmetrization of meso 1,2-bis(phenylsulfonyl)substituted bridged polycyclic alkenes promoted by C2 symmetric chiral diolates is reported. The phenylsulfonyl group exerts an electronwithdrawing effect onto the C-C double bond, making the alkenylic function a good Michael acceptor: enantiotopic Csp 2 react with the enantiopure nucleophile which has been used in stoichiometric amount. The stereoselective process leads to the formation of optically pure α-phenylsulfonylsubstituted polycyclic ketals, which are valuable intermediate in the synthesis of polycyclic α-phenyl sulfonylketones and ketones. The kinetic resolution of a racemic mixture of a tolylsulfonylsubstituted polycyclic alkene is also reported.


में अनुक्रमित

  • कैस
  • गूगल ज्ञानी
  • जे गेट खोलो
  • चीन राष्ट्रीय ज्ञान अवसंरचना (सीएनकेआई)
  • उद्धरण कारक
  • ब्रह्मांड IF
  • इलेक्ट्रॉनिक जर्नल्स लाइब्रेरी
  • रिसर्च जर्नल इंडेक्सिंग की निर्देशिका (डीआरजेआई)
  • गुप्त खोज इंजन लैब्स
  • आईसीएमजेई

और देखें

Flyer