अमूर्त
Effect Of GH-RH And Its Analogs On The Secretion Of Interleukin-18 And Tumor Necrosis Factor-ï¡ From Human Peripheral Blood Mononuclear Cells In Vitro
Henryk Stepien, Agnieszka Siejka, Jan Komorowski, Hanna Lawnicka, Tomasz Stepien, Roman Krupinski
The influence of GH-RH and GH-RH synthetic analogs (MZ-4-71, JV-1- 65 and JV-1-36) on TNF-ï¡ and IL-18 secretion from human peripheral blood mononuclear cells have been studied. GH-RH(1-29)NH2 and its analogs (JV-1-65 and JV-1-36) stimulated, but GH-RH(1-44)NH2 and MZ- 4-71 inhibited TNF-ï¡ secretion. Both GH-RH(1-29)NH2 and JV-1-65 significantly stimulated the secretion of IL-18. The results demonstrate for the first time the involvement of GH-RH and its analogs in the regulation of IL-18 and TNF-ï¡ï€ secretion from human leukocytes.
अस्वीकृति: इस सारांश का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया है और इसे अभी तक समीक्षा या सत्यापित नहीं किया गया है।
