अमूर्त

High Performance Liquid Chromatographic Assay Of Famotidine In Pharmaceuticals

K.Basavaiah, H.C.Prameela, U.Chandrashekar, B.C.Somashekar


A rapid assay method for the determination of famotidine in pharmaceutical preparations has been developed for assessment of product quality utilising high-performance liquid chromatography(HPLC). The HPLC separation could be undertaken on a reversed phase Accurasil SS C18 (5 m) column (25 cm x 4.6 mm i.d.) by using a mobile phase consisting of acetonitrile- 0.1% phosphoric acid (pH 3.0) (80:20) at a flow rate 1.0 ml/min. The detector wavelength was at 268 nm with a sensitivity of 0.2 a.u.f.s. The calibration graph was linear from 5.0 to 330 g/ml with the limits of detection(LOD) and qunatification(LOQ) being 1.0 and 3.0 g/ml, respectively. The method was validated according to the current ICH guidelines including assay of commercial tablets. Recoveries ranged from 96.28 to 102.21 %. The exipients present in the tablets did not interfere in the method.


में अनुक्रमित

  • कैस
  • गूगल ज्ञानी
  • जे गेट खोलो
  • चीन राष्ट्रीय ज्ञान अवसंरचना (सीएनकेआई)
  • उद्धरण कारक
  • ब्रह्मांड IF
  • इलेक्ट्रॉनिक जर्नल्स लाइब्रेरी
  • रिसर्च जर्नल इंडेक्सिंग की निर्देशिका (डीआरजेआई)
  • गुप्त खोज इंजन लैब्स
  • आईसीएमजेई

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