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Oxidimetric determination of mycophenolic acid in pure and pharmaceutical formulations

Ch.V.R.Murthy, M.L.N.Acharyulu, G.V.S.R.Pavan Kumar, S.V.Maruthi Prasad

Three simple and sensitive spectro photometric methods (A-C) have been developed for the estimation of Mycophenolic acid. Methods A&B are based on oxidation of the drug with oxidant (Potassium permanganate, Mno4 -,,Ferric chloride, Fe (III))followed by the estimation of un reacted oxidant with Fast green FCF (FGFCF).Method C involves the addition of excess CAT of a known concentration in the presence of 0.25MHCl and determining the un reacted CAT by measuring the absorbance of the Dye Gallocyanine. The absorption maxima were found to be at (Max 620nm for A,740 nm for B and 540 nm for C). These methods obey Beer’s law limits (1-10g/ml (A),2- 10g/ml (B) and 3-12g/ml (C)and give reproducible results. The percentage recoveries are99.02, 99.98 and 99.80 respectively.