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Simultaneous Estimation of Ezetimibe and Rosuvastatin in Drug Mixture by First Derivative Spectroscopic Method

S. J. Rajput and H. A. Raj

Derivative spectroscopy offers a useful approach for the analysis of drugs in multi-component mixtures. In this study, a first-derivative spectroscopic method was used for simultaneous determination of ezetimibe and rosuvastatin using the zero-crossing technique. The measurements were carried out at wavelengths of 290 and 245.6 nm for ezetimibe and rosuvastatin, respectively. The method was found to be linear (r2 > 0.9994) in the range of 5- 40 µg/mL for ezetimibe at 290 nm. The linear correlation was obtained (r2 > 0.9935) in the range of 5- 80 µg/mL for rosuvastatin at 245.6 nm. The limit of determination was 0.43 and 0.69 µg/mL for ezetimibe and rosuvastatin, respectively. The limit of quantification was 1.44 and 2.89 µg/mL for ezetimibe and rosuvastatin, respectively. The method was successfully applied for simultaneous determination of ezetimibe and rosuvastatin in drug mixture.