अमूर्त

Stability indicating methods for the determination of acyclovir in the presence of its degradation product

Hayam Mahmoud Lotfy, Mona M.Abd El-Moneim Abosen, Mohamed Galal EL-Bardicy


Two sensitive, selective and precise stability-indicating methods are presented for the determination of Acyclovir (ACV) in the presence of its degradate (Guanine). Method A depends on using first derivative of the ratio spectrophotometry (DD1) bymeasurement of the amplitude at 265 nm. Method B is based on a high performance liquid chromatographic (HPLC) separation of ACV from its degradation products using an ODS column with a mobile phase consisting of acetonitrile–distilled water (4:96, v/v,) with UV detection at 254 nm. Regression analysis showed good correlation in the concentration ranges 10-60 µgmL-1 and 20 – 120 µgmL-1with percentage recoveries of 100.06±0.89and 99.62±0.66 for methods A and B, respectively. These methods are suitable as stability indicating methods for the determination ofACV in presence of its degradation product either in bulk powder or in pharmaceutical formulation. Statistical analysis of the results has been carried out revealing high accuracy and good precision.


अस्वीकृति: इस सारांश का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया है और इसे अभी तक समीक्षा या सत्यापित नहीं किया गया है।

में अनुक्रमित

  • कैस
  • गूगल ज्ञानी
  • जे गेट खोलो
  • चीन राष्ट्रीय ज्ञान अवसंरचना (सीएनकेआई)
  • उद्धरण कारक
  • ब्रह्मांड IF
  • इलेक्ट्रॉनिक जर्नल्स लाइब्रेरी
  • रिसर्च जर्नल इंडेक्सिंग की निर्देशिका (डीआरजेआई)
  • गुप्त खोज इंजन लैब्स
  • आईसीएमजेई

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