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Structural character of -syn12 peptide in solution at high pH

Structural character of �?�?�?¯�?�?�?�?�?�?¡-syn12 peptide in solution at high pH

The dynamics and structural character of -syn12 peptide in aqueous solution at high pH has been investigated through temperature replica exchange molecular dynamics simulations by using GROMOS 43A1 force field. The isolated -syn12 peptide adopts in water an -helix structure at high pH. These results are distinct from other amyloid disease protein at neutral pH.