अमूर्त

Supplementation effects of vitamin C and vitamin E on oxidative stress in post menopausal diabetic women

Rosin Day, Sapna S.Lal

Introduction: Menopause is a natural event of women with cessation of menstrual cycle. Menopause is associated with a wide variety of physical and psychological symptoms. The antioxidant enzyme systems seem to be affected in this phase due to deficiency of estrogen, which has got antioxidant properties. Oxidative stress occurs at menopause because of loss of estrogens, which have antioxidant effect on lowdensity lipoproteins. Diabetes is also a degenerative disease usually accompanied by increased production of free radicals or impaired antioxidant defenses. Keeping these two real fact on the mind the present study has been design, if menopausal women will suffer from the type II diabetes this problem of high production of free radical become very complicated or leading to death. Objective: the main objective of the study is asses the supplementation effect of vitamin E and Vitamin C on oxidative stress markers and antioxidant enzyme level with and without type II diabetic menopausal women. Material and Method: Blood sample of menopausal women age group with or without diabetes was collected from different hospitals of Allahabad. Serum antioxidant enzyme -Glutathione redutase,superoxide dismutase and catalase was estimated. Serum Melondialdehyde was also estimated as strees marker. Results: it is reveals from the study that, supplementation of vitamin C and vitamin E reduces the oxidative stress and increases the antioxidant serum enzyme level. Data shows that vitamin E is most effective than vitamin C. Conclusion:it is concluded from the study that diabetic menopausal women, with supplementation of vitamin E have less risk of developing oxidative stress.